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Use the buttons below to access the order form and to request a pre-paid shipping box from iKaryos Diagnostics.

Please note: It is critical that a hematopathology and flow cytometry or surgical pathology report accompany the specimen to our laboratory.

This will enable proper tumor enrichment and a more useful clinicopathologic correlation. In addition, please indicate on the requisition the medical professional who is the point of contact for the case.

Hematologic Cancers (Peripheral blood or bone marrow aspirate)

Please provide a copy of the flow cytometry and hematopathology reports. These reports can accompany the specimen or be faxed to (402) 559-9497. For hematologic specimens, the initial step in specimen processing may be enrichment for the clonal population using density-based or magnetic bead methods. The immunophenotype of the clonal population will guide the enrichment. This enrichment step results in a more robust SNP array profile and enables the detection of small subclones. DNA is extracted after enrichment. For lymph nodes, please see the directions for solid tumors below. To minimize extremes of heat/cold during shipping, please send the sample with a cold pack. Pre-paid shipping packages from iKaryos are available by clicking on the button above.

Solid Tumors

Please attached a copy of the surgical pathology report to the requisition for SNP array analysis. Fresh tissue will always provide a cleaner SNP array profile, but paraffin embedded tissue is also acceptable. For paraffin embedded samples, we request ten 10 μm unstained slides plus one H&E. There must be at least 0.3 cm of tumor present on each slide. Please have a pathologist select a block that has minimal ‘normal clone contamination’ from inflammatory cells, stromal cells, and other non-neoplastic cells. We perform manual microdissection of tumor cells prior to DNA extraction in order to enrich for the clonal population. Alternatively, you can send the paraffin block, and we will return the block after sectioning. To minimize extremes of heat/cold during shipping, please send blocks or slides with a cold pack. Pre-paid shipping packages from iKaryos are available by clicking on the button above.

SampleRequired RecordSample Requirements
Hematopathology samplesFlow cytometry and hematopathology reportsBlood: 1-5 mL in EDTA (purple top). Ship with cold pack.
Bone marrow: 1-5 mL in EDTA (purple top). Ship with cold pack.
Solid tumorsSurgical pathology reportTen x 10 μm unstained slides plus one H&E section. Ship with cold pack. OR
Paraffin block. Ship with cold pack.
OR
Fresh/frozen tissue. Ship on dry ice.
Other sample types Please contact us as we can process other sample types and research samples